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SCIENTIFIC SCORE
Moderately Effective
Based on 25 Researches
8
USERS' SCORE
Good
Based on 16 Reviews
8.8
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Vitamin B6 (as Pyridoxal-5-Phosphate)
1.5 mg
88%
Folate (400 mcg as (6S)-5-MTHF [from (6S)-5-Methyltetrahydrofolate Glucosamine Salt])
680 mcg DFE‡
170%
Vitamin B12 (as Methylcobalamin)
1,000 mcg
41,667%
Top Medical Research Studies
9
Folic acid reduces CHD risk
Association of maternal folic acid supplementation and offspring MTRR gene polymorphism with congenital heart disease: a hospital-based case-control study in Han population.
Study directly links folate to heart health
We conducted a case-control study to look into how maternal folic acid supplementation affects the risk of congenital heart disease (CHD) in children and whether genetic factors, specifically MTRR gene polymorphisms, play a role in this relationship.
Our research involved 595 children diagnosed with CHD and 605 healthy children. By using a multivariate logistic regression model, we were able to assess the impact of maternal folate intake and the offspring's genetic profiles on the likelihood of developing CHD and its various subtypes.
The findings were quite striking. We observed that children whose mothers took folic acid during pregnancy showed a significantly reduced risk of CHD. Specifically, this included notable reductions in certain types of heart defects such as atrial septal defect and ventricular septal defect. Interestingly, specific polymorphisms in the MTRR gene were also linked to an increased risk of CHD.
Most importantly, we found that when mothers supplemented with folic acid, it appeared to mitigate some of the risks associated with genetic variants in their children. However, we recognize the need for additional studies with larger populations and different designs to confirm these important findings.
Our research involved 595 children diagnosed with CHD and 605 healthy children. By using a multivariate logistic regression model, we were able to assess the impact of maternal folate intake and the offspring's genetic profiles on the likelihood of developing CHD and its various subtypes.
The findings were quite striking. We observed that children whose mothers took folic acid during pregnancy showed a significantly reduced risk of CHD. Specifically, this included notable reductions in certain types of heart defects such as atrial septal defect and ventricular septal defect. Interestingly, specific polymorphisms in the MTRR gene were also linked to an increased risk of CHD.
Most importantly, we found that when mothers supplemented with folic acid, it appeared to mitigate some of the risks associated with genetic variants in their children. However, we recognize the need for additional studies with larger populations and different designs to confirm these important findings.
Read More
9
Vitamin B12 helps heart recovery
Vitamin B12 alleviates myocardial ischemia/reperfusion injury via the SIRT3/AMPK signaling pathway.
Directly addresses vitamin B12 effects
We explored how vitamin B12 can act as a safeguard against heart damage caused by ischemia/reperfusion (I/R) injury. In our study, we used a mouse model subjected to I/R injury by occluding the left anterior descending coronary artery, followed by 24 hours of reperfusion.
Our aim was to see if high doses of vitamin B12 could improve heart function and reduce damage. Through various evaluations, including echocardiography and biochemical methods, we revealed that vitamin B12 supplementation does indeed help. It mitigates oxidative stress and lowers levels of harmful reactive oxygen species.
Additionally, we found that B12 supplementation reduced cell apoptosis—essentially cell death—in heart tissues. This response was linked to the action of specific signaling pathways, particularly the SIRT3/AMPK pathway. However, we noted that these protective effects diminished when a SIRT3 inhibitor was introduced, indicating the importance of this pathway.
Moreover, RNA sequencing data showed that vitamin B12 also plays a role in reducing inflammation during I/R injury. Overall, our findings suggest that high doses of vitamin B12 might serve as an effective strategy for treating myocardial damage from I/R events, potentially paving the way for new therapies in heart health.
Our aim was to see if high doses of vitamin B12 could improve heart function and reduce damage. Through various evaluations, including echocardiography and biochemical methods, we revealed that vitamin B12 supplementation does indeed help. It mitigates oxidative stress and lowers levels of harmful reactive oxygen species.
Additionally, we found that B12 supplementation reduced cell apoptosis—essentially cell death—in heart tissues. This response was linked to the action of specific signaling pathways, particularly the SIRT3/AMPK pathway. However, we noted that these protective effects diminished when a SIRT3 inhibitor was introduced, indicating the importance of this pathway.
Moreover, RNA sequencing data showed that vitamin B12 also plays a role in reducing inflammation during I/R injury. Overall, our findings suggest that high doses of vitamin B12 might serve as an effective strategy for treating myocardial damage from I/R events, potentially paving the way for new therapies in heart health.
Read More
8
Pyridoxamine aids heart health
Pyridoxamine Alleviates Cardiac Fibrosis and Oxidative Stress in Western Diet-Induced Prediabetic Rats.
Strong relevance to heart disease
We explored the effects of pyridoxamine (PM), a form of vitamin B6, on heart health in a study involving male rats. These rats were divided into two groups: one received a standard diet, while the other was fed a Western diet known to induce prediabetes. To see how PM might help, we gave one group of rats on the Western diet an additional PM supplement through their drinking water for 18 weeks.
Throughout the study, we measured glucose levels and evaluated heart function using echocardiography, alongside analyzing heart tissue for any changes. Remarkably, the rats that received PM showed less increase in fasting blood glucose compared to those on the Western diet alone. Additionally, the PM treatment seemed to prevent some heart enlargement that typically occurs alongside unhealthy diets.
Furthermore, PM was effective in limiting collagen buildup within the heart tissue, which is often a marker of heart stress or damage. We also noted a reduction in substances related to oxidative stress, suggesting that PM might protect against heart damage by reducing harmful compounds. In summary, our findings suggest that pyridoxamine may help alleviate issues related to heart structure and stress in rats at risk of developing heart disease due to prediabetes.
Throughout the study, we measured glucose levels and evaluated heart function using echocardiography, alongside analyzing heart tissue for any changes. Remarkably, the rats that received PM showed less increase in fasting blood glucose compared to those on the Western diet alone. Additionally, the PM treatment seemed to prevent some heart enlargement that typically occurs alongside unhealthy diets.
Furthermore, PM was effective in limiting collagen buildup within the heart tissue, which is often a marker of heart stress or damage. We also noted a reduction in substances related to oxidative stress, suggesting that PM might protect against heart damage by reducing harmful compounds. In summary, our findings suggest that pyridoxamine may help alleviate issues related to heart structure and stress in rats at risk of developing heart disease due to prediabetes.
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Most Useful Reviews
9.5
Heart health improvements
Finding this supplement was a revelation; it combines active folic acid and B12 in a sublingual form, helping absorption and potentially lowering heart disease risks. I noticed a lift in mood and energy shortly after taking it. The slight chemical sweet taste is the only downside for me.
Read More
8.3
Lowers homocysteine quickly
Many gynecologists recommend folic acid for pregnancy, yet most forms in Russia are inactive. This complex includes effective methyl forms of B vitamins. I take these with TMG to significantly lower homocysteine levels, crucial for heart disease prevention. It's effective and easy to absorb sublingually.
Read More
9.5
Reduces homocysteine
This supplement lowers homocysteine, a marker for heart disease, particularly when taken with Jarrow TMG. My levels normalised within two months. I take one tablet after a meal but avoid coffee or tea around that time. It’s important for overall health.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 25 Researches
8
9.5
Folate's role in heart protection
Folate as a potential treatment for lethal ventricular arrhythmias in TANGO2-deficiency disorder.
Focus on folate for TDD
We explored the effects of folate, a form of vitamin B, on heart problems associated with TANGO2-deficiency disorder (TDD). This genetic condition can lead to dangerous heart rhythms that don’t respond well to standard treatments. To dive deeper into this issue, we established patient-derived heart cells, known as iPSC-CMs, to mimic the heart abnormalities seen in TDD.
In our observations, we found that high doses of folate almost completely eliminated arrhythmias in these heart cells. Interestingly, our clinical observations revealed that TDD patients taking multivitamins, particularly those high in B vitamins, experienced a significant reduction in cardiac crises. This suggests that folate may play a critical role in protecting against these life-threatening heart issues.
Our findings not only highlight the potential of folate as an effective treatment but also emphasize the importance of considering dietary supplements in managing cardiac risks in patients with TDD. Thus, we believe that boosting folate intake could offer a valuable strategy to enhance heart health in those affected by this disorder.
In our observations, we found that high doses of folate almost completely eliminated arrhythmias in these heart cells. Interestingly, our clinical observations revealed that TDD patients taking multivitamins, particularly those high in B vitamins, experienced a significant reduction in cardiac crises. This suggests that folate may play a critical role in protecting against these life-threatening heart issues.
Our findings not only highlight the potential of folate as an effective treatment but also emphasize the importance of considering dietary supplements in managing cardiac risks in patients with TDD. Thus, we believe that boosting folate intake could offer a valuable strategy to enhance heart health in those affected by this disorder.
Read More
9
Vitamin B6 shows heart health promise
Protective effects of pyridoxine, amlodipine, and their combination in a vasopressin-induced angina model in rats.
Limited relevance to heart disease
We explored the effects of vitamin B6 (pyridoxine) on heart health, specifically looking at its protective qualities against angina provoked by vasopressin in a rat model. Vasopressin was administered to observe its impact on heart function, which included elevated stress on the heart indicated by changes on the electrocardiogram and increased cardiac enzymes.
The study found that when we gave rats pyridoxine in varying doses, it effectively reduced the ST elevation and heart rate changes caused by vasopressin. Notably, higher doses of pyridoxine (7 mg/kg) showed significant protective effects, outperforming both amlodipine and isosorbide. In addition, we observed that pyridoxine at these doses helped prevent cardiac tissue damage and improved heart structure.
Interestingly, while combining pyridoxine with amlodipine led to a trend of increased adverse cardiovascular events, the results underscored the potential of vitamin B6 in enhancing heart health. It appears vitamin B6 may work by improving certain functions in the body that support heart health, such as better blood vessel function and reduced levels of harmful substances.
Overall, our findings suggest that vitamin B6 could serve as a promising agent in preventing coronary heart disease, but more research is necessary to fully explore its benefits and practical applications in humans.
The study found that when we gave rats pyridoxine in varying doses, it effectively reduced the ST elevation and heart rate changes caused by vasopressin. Notably, higher doses of pyridoxine (7 mg/kg) showed significant protective effects, outperforming both amlodipine and isosorbide. In addition, we observed that pyridoxine at these doses helped prevent cardiac tissue damage and improved heart structure.
Interestingly, while combining pyridoxine with amlodipine led to a trend of increased adverse cardiovascular events, the results underscored the potential of vitamin B6 in enhancing heart health. It appears vitamin B6 may work by improving certain functions in the body that support heart health, such as better blood vessel function and reduced levels of harmful substances.
Overall, our findings suggest that vitamin B6 could serve as a promising agent in preventing coronary heart disease, but more research is necessary to fully explore its benefits and practical applications in humans.
Read More
9
Vitamin B6 aids heart recovery
Vitamin B6 allosterically activates AMPK to promote postischemic angiogenesis in mice.
Study focused on B6 benefits
We explored the effects of vitamin B6 (VB6) on heart recovery after an acute myocardial infarction (AMI). The study aimed to determine if VB6 could promote angiogenesis, the process of new blood vessel formation, which is crucial for healing the heart after such an event.
To investigate this, we looked at the ability of VB6 to enhance cell migration and tube formation in human umbilical vein endothelial cells, which are key players in the formation of blood vessels. Our results showed that VB6 not only encouraged these processes but also increased the phosphorylation of AMPK, a protein that plays a vital role in cellular energy regulation.
Importantly, these beneficial effects of VB6 on cell behavior were found to depend on AMPK activation. When we used specific inhibitors to block AMPK, the positive changes from VB6 were no longer observed. Additionally, in an animal model, long-term supplementing with VB6 led to significant improvements in heart function, more new blood vessel growth, and reduced inflammation markers in mice after AMI.
In summary, our findings suggest that vitamin B6 could be an effective support for heart recovery due to its role in promoting angiogenesis through AMPK activation following heart attacks. Given that VB6 shows promise in limiting ischemic heart injury, it could be a valuable addition to existing heart disease treatments.
To investigate this, we looked at the ability of VB6 to enhance cell migration and tube formation in human umbilical vein endothelial cells, which are key players in the formation of blood vessels. Our results showed that VB6 not only encouraged these processes but also increased the phosphorylation of AMPK, a protein that plays a vital role in cellular energy regulation.
Importantly, these beneficial effects of VB6 on cell behavior were found to depend on AMPK activation. When we used specific inhibitors to block AMPK, the positive changes from VB6 were no longer observed. Additionally, in an animal model, long-term supplementing with VB6 led to significant improvements in heart function, more new blood vessel growth, and reduced inflammation markers in mice after AMI.
In summary, our findings suggest that vitamin B6 could be an effective support for heart recovery due to its role in promoting angiogenesis through AMPK activation following heart attacks. Given that VB6 shows promise in limiting ischemic heart injury, it could be a valuable addition to existing heart disease treatments.
Read More
9
Vitamin B-6 aids heart health
Vitamin B-6 Prevents Heart Failure with Preserved Ejection Fraction Through Downstream of Kinase 3 in a Mouse Model.
Relevant but dietary factors involved
We examined how vitamin B-6 might play a role in preventing heart failure with preserved ejection fraction (HFpEF), a condition that often results from changes in heart-related immune cells called macrophages. Our research was based on a mouse model that mimicked HFpEF through a high-fat diet paired with a specific supplement. By monitoring heart function using various imaging techniques, as well as examining heart tissue for changes, we gathered important insights into vitamin B-6's potential benefits.
We found that when vitamin B-6 was added to the diet of mice prone to HFpEF, it significantly improved several heart failure symptoms. There were notable enhancements in heart function, reducing pressure in the heart and allowing for better exercise capacity. However, we made a crucial discovery: the positive effects of vitamin B-6 were diminished when we examined mice lacking a specific protein called DOK3. This suggests that DOK3 is key to vitamin B-6’s success in mitigating heart failure symptoms.
Essentially, our findings indicate that vitamin B-6 might lower the risk of heart failure by halting harmful changes in cardiac macrophages thanks to its ability to boost DOK3 signaling. This research offers exciting possibilities for a new therapeutic approach aimed at improving heart health and managing HFpEF effectively.
We found that when vitamin B-6 was added to the diet of mice prone to HFpEF, it significantly improved several heart failure symptoms. There were notable enhancements in heart function, reducing pressure in the heart and allowing for better exercise capacity. However, we made a crucial discovery: the positive effects of vitamin B-6 were diminished when we examined mice lacking a specific protein called DOK3. This suggests that DOK3 is key to vitamin B-6’s success in mitigating heart failure symptoms.
Essentially, our findings indicate that vitamin B-6 might lower the risk of heart failure by halting harmful changes in cardiac macrophages thanks to its ability to boost DOK3 signaling. This research offers exciting possibilities for a new therapeutic approach aimed at improving heart health and managing HFpEF effectively.
Read More
9
Pyridoxamine protects heart during chemotherapy
Pyridoxamine Attenuates Doxorubicin-Induced Cardiomyopathy without Affecting Its Antitumor Effect on Rat Mammary Tumor Cells.
Relevant cardioprotectant in cancer treatment
We focused on how pyridoxamine, a form of vitamin B6, impacts heart health during treatment with doxorubicin, a common cancer drug. In an experimental setup with Sprague Dawley rats, we observed that those receiving doxorubicin experienced a decrease in heart function, specifically a reduced left ventricular ejection fraction, and an increase in heart volume.
Notably, when we added pyridoxamine to the treatment, these harmful effects were significantly lessened. The rats that took pyridoxamine alongside doxorubicin maintained better heart function compared to those who only received doxorubicin. This suggests that pyridoxamine acts as a protective agent for the heart, countering some of the negative impacts caused by doxorubicin.
However, we also investigated how doxorubicin and pyridoxamine affected breast cancer cells in the lab. While doxorubicin effectively reduced cancer cell viability and increased cell death, pyridoxamine didn’t change these outcomes. This indicates that while pyridoxamine can preserve heart health during chemotherapy, it doesn’t interfere with the cancer-fighting effects of doxorubicin.
Overall, this research highlights pyridoxamine's promising role as a cardioprotectant during cancer treatment, allowing for heart preservation without diminishing the effectiveness of anticancer therapies.
Notably, when we added pyridoxamine to the treatment, these harmful effects were significantly lessened. The rats that took pyridoxamine alongside doxorubicin maintained better heart function compared to those who only received doxorubicin. This suggests that pyridoxamine acts as a protective agent for the heart, countering some of the negative impacts caused by doxorubicin.
However, we also investigated how doxorubicin and pyridoxamine affected breast cancer cells in the lab. While doxorubicin effectively reduced cancer cell viability and increased cell death, pyridoxamine didn’t change these outcomes. This indicates that while pyridoxamine can preserve heart health during chemotherapy, it doesn’t interfere with the cancer-fighting effects of doxorubicin.
Overall, this research highlights pyridoxamine's promising role as a cardioprotectant during cancer treatment, allowing for heart preservation without diminishing the effectiveness of anticancer therapies.
Read More
User Reviews
USERS' SCORE
Good
Based on 16 Reviews
8.8
9.5
Heart health improvements
Finding this supplement was a revelation; it combines active folic acid and B12 in a sublingual form, helping absorption and potentially lowering heart disease risks. I noticed a lift in mood and energy shortly after taking it. The slight chemical sweet taste is the only downside for me.
Read More
9.5
Aids heart function
I switched to this more affordable complex to lower my homocysteine. It’s vital for preventing heart disease, and I'm pleased with the results—my homocysteine dropped significantly, and it’s particularly important for women trying to conceive.
9.5
Protection against disease
I take Jarrow Formulas each morning to regulate my homocysteine, as high levels can damage my arteries and increase heart disease risk. Complementing it with Omega-3 seems effective for my overall heart health.
9.5
Lowers cholesterol risk
After taking this supplement, my cholesterol levels improved significantly. It’s integral to managing heart disease risk alongside dietary changes and exercise.
9.5
Reduces homocysteine
This supplement lowers homocysteine, a marker for heart disease, particularly when taken with Jarrow TMG. My levels normalised within two months. I take one tablet after a meal but avoid coffee or tea around that time. It’s important for overall health.
